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Multiple Sclerosis

Introduction and Goals

The MS and clinical neuro-immunology elective is an outpatient clinical rotation supervised by Drs. Natasha Frost and Chris Luzzio. The goals are for the resident to:

  • Identify and classify CNS demyelinating and inflammatory diseases
  • Demonstrate working differential diagnosis of the patient with a demyelinating disease and understand distinguishing clinical features
  • Know appropriate work-up for major symptoms/syndromes/diseases
  • Implement a reasonable treatment plan
  • Realize long term complications of treatment modalities
  • Be familiar with indications for immune-modulating therapies
  • Demonstrate knowledge of the management of symptoms and chronic disease

Objectives and Evaluation Matrix

As with all of the neurology rotations, the specific objectives are reflected in the entrustable professional activities and individual milestones listed below. These form the basis for the end-of-rotation evaluation. (Please see the section End-of-Rotation Evaluations above for the list of milestone abbreviations).


Below is a sample schedule for this rotation. This schedule is subject to attending availability; accordingly, this elective may not be able to be offered during weeks when multiple attendings are out of clinic (for example, national conference weeks or holidays).

The below schedule can, within certain parameters, be adjusted to address specific resident learning goals for the rotation. If there are specific requests for scheduling, these should be included in the elective request form and sent to Sara Nagel and Sam Jenson. An individualized schedule will be emailed to the resident the week before the rotation. 

MS Schedule_0.JPG

Work Hours

The estimated number of work hours per week is 32. There is no call responsibility during this rotation.

Suggested References

Cohen, J. A., & Rudick, R. A. (2011). Multiple sclerosis therapeutics. Cambridge, UK; New York: Cambridge University Press.

Crayton, H., Heyman, R. A., & Rossman, H. S. (2004). A multimodal approach to managing the symptoms of multiple sclerosis. Neurology, 63(11 Suppl 5), S12–8.

Fleming, J. O., & Carrithers, M. D. (2010). Diagnosis and management of multiple sclerosis: a handful of patience. Neurology, 74(11), 876–7. doi:10.1212/WNL.0b013e3181d561c8

Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., … Wolinsky, J. S. (2011). Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Annals of Neurology, 69(2), 292–302. doi:10.1002/ana.22366

Rolak, L. A., & Fleming, J. O. (2007). The differential diagnosis of multiple sclerosis. The Neurologist, 13(2), 57–72. doi:10.1097/01.nrl.0000254705.39956.34

Wingerchuk, D. M., & Carter, J. L. (2014). Multiple sclerosis: current and emerging disease-modifying therapies and treatment strategies. Mayo Clinic Proceedings, 89(2), 225–40. doi:10.1016/j.mayocp.2013.11.002

Latest revision: 07-03-2019