Faculty Research

Carl Stafstrom

Lab Location: MSC (Service Memorial Institute)

Contact Info:
CSC H6/528
Secretary: 608.263.8551
Email: stafstrom@neurology.wisc.edu
Faculty Profile: Dr. Stafstrom
Publications: PubMed
Provider page: UW Health

Research

Mechanisms of Epileptogenesis and Neuronal Excitability in the Developing Brain

My research focuses on the mechanisms and consequences of seizures in the developing brain. During development, the brain is more prone to seizures, yet the long-term consequences are less severe than in the mature brain. The physiological factors underlying this differential susceptibility have not been clarified. Using a variety of epilepsy models, we are evaluating the age-dependent features of epileptogenesis, with the ultimate goal of optimizing seizure treatment in the pediatric age group.

Particular emphasis is on understanding the mechanisms of epilepsy dietary treatments, such as the ketogenic diet. This high fat, low carbohydrate/protein diet has been used for intractable epilepsy for nearly a century, but its mechanism of action is unknown. The ketogenic diet shifts brain metabolism from utilization of carbohydrates to fats as the primary energy source. The antiepileptic effect is presumed to be secondary to the ketosis produced by the diet, but this does not fully explain the effect.

The laboratory utilizes multiple techniques, including extracellular/intracellular/patch recording, in vivo recording including lng-term EEG monitoring, behavior testing (Morris water maze, elevated plus maze, open field), and histological techniques.