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| 2006 board of regents of the uw system file last updated October 20, 2009 neurology inquiries: www.uwhealth.org web feedback: webmaster@neurology.wisc.edu |
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Kenneth J. O'Riordan, BSc
Biochemistry and Genetics
University of Sheffield, UK
6 years lab specialist within neuroscience
I have a variety of lab experience from rat pup hippocampal acute and chronic slice culturing to slice electrophysiology and the study of the biochemical pathways involved in learning and memory. My current project involves identifying the role metabolism plays in the biochemical process of memory consolidation and storage. The cutting edge techniques being implemented include acute hippocampal slice electrophysiology, shRNA viral gene delivery into the hippocampus, and acute hippocampal slice in vitro drug application.
Publications:
J.M. Levenson, P. Mukhopadhyay, K.P. Mangan, K.J. O'Riordan (2008) Vertebrate models of learning and memory: Synaptic plasticity underlying contextual and cued fear conditioning. Encylopedia of Neuroscience 4th Ed. (In Press).
H. Kaphzan, K.J. O'Riordan, K.P. Mangan, J.M. Levenson, K. Rosenblum, (2006 ) NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus. PLoS ONE, Dec 27;1:e138.
K.J. O’Riordan, I.-C. Huang, P.F. Spano, F. Boroni, P. Desai, H.-C. Liou, M. Pizzi, J.D. Sweatt, J.M. Levenson (2006) Regulation of NF-kB in the Hippocampus by Group I Metabotropic Glutamate Receptors. Journal of Neuroscience, 3;26(18):4870-9.
W.B. Chwang, K.J. O’Riordan, J.M. Levenson, J.D. Sweatt (2006) ERK/MAPK Regulates Hippocampal Histone Phosphorylation in Contextual Fear Conditioning. Learning and Memory, 13(3):322-8.
J.M. Levenson, K.J. O’Riordan, K.D. Brown, M.A. Trinh, D. Molfese, J.D. Sweatt (2004) Regulation of Histone Acetylation During Memory Formation in the Hippocampus. Journal of Biological Chemistry, 279(39): 40545-40559.
K.A. Bell, K.J. O’Riordan, J.D. Sweatt, K.T. Dineley (2004) MAPK Recruitment by β-Amyloid in Organotypic Hippocampal Slice Cultures Depends on Physical State and Exposure Time, Journal of Neurochemistry, 91(2): 349-61.